Yes and no. To get the very best out of it yes, but if you are just going to grow a little weed then just use twice as much as you would for as vegetable plant. Jan. I took a "metal cattle water-trough" full and dumped it into an area the size of a 6ft truck bed, 1 bucket of wood-ash, 1 big handful of bone meal and worked it into the soil and limed it good, this is how I fix a place in the woods each year. If I had a spring as good as last year my plants would be close to 6ft tall now. But it is really better to let it age first in a pile or in the soil or in a compost bin, guess that is why they say if you use the same place every year it gets better.
Get a bag of cow manure from wal-mart to plant your clones, mix it in the soil and plant them. As you go along you can add more and different nutrients to the plants, lime makes the ph normal, helps plants use nutrients in the soil better, breaks down organic matter pretty much a soil conditioner. A plant will tell you when it needs water just by looking at it, if it is wilted somewhat then it is thirsty, but a good rule of thumb is just stick your finger in the soil if it feels damp or cool then it is fine regardless of what someone say all soil is different but they take around a gallon per week on an average some more some less. Best just look at the plants is the best way.
You'll do fine as long as you can grow a flower, it's just as easy, Just give the plants what they want and LEAVE THEM ALONE. Plants need no interference from humans to grow and do alot better if humans don't touch them. (no offense)