Black Folks and Aids

earnest_voice · Jul 21, 2014

desert dude said:
EV. Genes are racist. That's all a good progressive needs to remember.

So are we still talking about the OP? (Why so many African Americans have HIV/AIDS?) The case study you cited goes a little ways to explaining your position but also mentions the outcome with this patient was also a result of discontinuing the antiviral treatment and the effect that had on the CXCR4 coreceptor.

http://www.nejm.org/doi/full/10.1056/NEJMoa0802905#t=article

This observation is remarkable because homozygosity for CCR5 delta32 is associated with high but not complete resistance to HIV-1. This outcome can be explained by the behavior of non-CCR5-tropic variants, such as CXCR4-tropic viruses (X4), which are able to use CXCR4 as a coreceptor. The switch occurs in the natural course of infection, and the proportion of X4 increases with ongoing HAART.

The lack of this genetic mutation in African Americans doesn't explain the prevalence of HIV/AIDS amongst them. I think the factors are too varied to narrow it down to any particular cause. IMO it would be a number of factors compounded by their individual situation.

DonAlejandroVega · Jul 21, 2014

desert dude said:
You can call me Heisenberg.

it really all depends..........

DonAlejandroVega · Jul 21, 2014

desert dude said:
I think this is Werner Heisenberg but I am not certain. A little physics humor for the progs to scratch their heads over.

Ha....my quip.....two posts up.........

DonAlejandroVega · Jul 21, 2014

desert dude said:

I would say to dude......"I don't want to look at your package.......please cover that shit up.......freak"

desert dude · Jul 21, 2014

earnest_voice said:
So are we still talking about the OP? (Why so many African Americans have HIV/AIDS?) The case study you cited goes a little ways to explaining your position but also mentions the outcome with this patient was also a result of discontinuing the antiviral treatment and the effect that had on the CXCR4 coreceptor.

http://www.nejm.org/doi/full/10.1056/NEJMoa0802905#t=article

The lack of this genetic mutation in African Americans doesn't explain the prevalence of HIV/AIDS amongst them. I think the factors are too varied to narrow it down to any particular cause. IMO it would be a number of factors compounded by their individual situation.

Is the delta32 mutation the sole explanation for decreased susceptibility amongst northern Europeans? Probably not, but it probably is the major explanation. To completely discount it is just dumb given the biological evidence, and the population statistics that show that about 10% (not 1%) of northern Europeans are resistant or immune to HIV-1.

SmokeyDan · Jul 21, 2014

White people are so self absorbed that they don't even let themselves die of the same stuff as other people.

Sativied · Jul 21, 2014

desert dude · Jul 21, 2014

earnest_voice said:
So are we still talking about the OP? (Why so many African Americans have HIV/AIDS?) The case study you cited goes a little ways to explaining your position but also mentions the outcome with this patient was also a result of discontinuing the antiviral treatment and the effect that had on the CXCR4 coreceptor.

http://www.nejm.org/doi/full/10.1056/NEJMoa0802905#t=article

The lack of this genetic mutation in African Americans doesn't explain the prevalence of HIV/AIDS amongst them. I think the factors are too varied to narrow it down to any particular cause. IMO it would be a number of factors compounded by their individual situation.

Discontinuing the antiviral treatment with no rebound in the virus is "the proof in the pudding", i.e. that is the proof that the CCR5 delta32 transplant suppressed the HIV infection. Before the stem cell transplant, they discontinued the antiviral treatment and the HIV load in the guy's blood went through the roof, after the transplant there was no need for antivirals.

Either you did not read the paper you linked to, or you misinterpreted what you read, or you are trying to fog up the conversation with BS. If you were one of the usual lefties, I would conclude you were lying, but since I don't know you I will give you the benefit of the doubt and conclude you simply did not understand what you read.

DonAlejandroVega · Jul 21, 2014

Sativied said:

they gave it away in the instructions. there's no mystery now.................

heckler73 · Jul 21, 2014

desert dude said:
I think this is Werner Heisenberg but I am not certain. A little physics humor for the progs to scratch their heads over.

$gif.latex$

A dur hur hur... I want to hear more about stem cells!

Sativied · Jul 21, 2014

DonAlejandroVega said:
they gave it away in the instructions. there's no mystery now.................

Without the instructions people would merely be connecting dots randomly :rolleyes:

heckler73 · Jul 21, 2014

Sativied said:
Without the instructions people would merely be connecting dots randomly

I was using the uncertainty principle to guide my pencil...

earnest_voice · Jul 21, 2014

desert dude said:
Discontinuing the antiviral treatment with no rebound in the virus is "the proof in the pudding", i.e. that is the proof that the CCR5 delta32 transplant suppressed the HIV infection. Before the stem cell transplant, they discontinued the antiviral treatment and the HIV load in the guy's blood went through the roof, after the transplant there was no need for antivirals.

Either you did not read the paper you linked to, or you misinterpreted what you read, or you are trying to fog up the conversation with BS. If you were one of the usual lefties, I would conclude you were lying, but since I don't know you I will give you the benefit of the doubt and conclude you simply did not understand what you read.

You need to go back and read the links as I think it is you who is confused. You've cherry picked one case and used it to justify your flimsy position. And no the homozygous delta32 mutation is only found in up to 1% of the population. 10% - 18% carry a single copy and by itself it isn't a guarantee against infection.

If you think this is why African Americans are impacted by HIV/AIDs on a greater level, you're fucked in the head.

Red1966 · Jul 21, 2014

SmokeyDan said:
I think HIV might have been developed specifically to target blacks at a time when science couldn't do much better.

obviously it infects all human populations, but all things being equal, blacks are the most affected.

Yeah, AIDS is a secret plot by whitey to kill off the black man.

Red1966 · Jul 21, 2014

SmokeyDan said:
I'm not a geneticist. And i cant provide you a source, mostly because the truth isn't really important to me on this topic, so I don't really want to expend time searching for it.

I just so happened to be listening to something on the radio, I think it was coast to coast am with George Nory.

White people of northern Europe have a gene that provides resistance to hiv.

This would explain gay men who have had partners die from aids and yet they remain hiv negative.

This gene is fairly common in northern European whites, and uncommon in other populations, particularly blacks, who happen to be the most susceptible to developing a hiv infection.

That is not to say those whites are immune, just more resistant.

That's what the radio said. I have no idea how true it is.

Anything you hear on Coast to Coast AM with George Nory can safely assumed to be total nut wing.

desert dude · Jul 21, 2014

earnest_voice said:
You need to go back and read the links as I think it is you who is confused. You've cherry picked one case and used it to justify your flimsy position. And no the homozygous delta32 mutation is only found in up to 1% of the population. 10% - 18% carry a single copy and by itself it isn't a guarantee against infection.

If you think this is why African Americans are impacted by HIV/AIDs on a greater level, you're fucked in the head.

I didn't cherry pick anything. The one case is, so far as I know, the only case with a stem cell transplant using homozygous delta 32 stem cells.

The research indicates that heterozygous delta32 people suffer reduced symptoms, and delayed onset of illness when they do get HIV. Something like 20% of Caucasians are heterozygous. Slowed progression of the illness corresponds to slowed transmission of the virus. http://www.mcld.co.uk/hiv/?q=delta32

Since you are an expert on African-American susceptibility to HIV infection would you care to enlighten me why Af-AMs are infected at 8 times the rate of northern Europeans with something a little more convincing than hand waving and name calling?

Finally, I linked to the single case of the stem cell transplant because it is so damn remarkable and interesting and it demonstrates that those who have two copies of delta32 are nearly 100% immune to infection.

earnest_voice · Jul 21, 2014

desert dude said:
I didn't cherry pick anything. The one case is, so far as I know, the only case with a stem cell transplant using homozygous delta 32 stem cells.

The research indicates that heterozygous delta32 people suffer reduced symptoms, and delayed onset of illness when they do get HIV.

Since you are an expert on African-American susceptibility to HIV infection would you care to enlighten me why Af-AMs are infected at 8 times the rate of northern Europeans with something a little more convincing than hand waving and name calling?

Finally, I linked to the single case of the stem cell transplant because it is so damn remarkable and interesting.

Read the link in the OP :wall:

I've outlined the most obvious reasons in previous posts and genes have nothing to do with it.

The CDC outlined the case to with no mention of the delta 32 mutation or lack thereof. For some reason you think a mutant gene found in just 1% of white people is the reason African Americans CONTRACT HIV at higher rates? That's just dishonest, even for you

Red1966 · Jul 21, 2014

DonAlejandroVega said:
kosher is not healthy. I eat healthy

I eat dead animals, so not healthy.

Red1966 · Jul 21, 2014

londonfog said:
so when you meet men in Vegas they try to fuck you ??
When we meet up it's usually to see a fight or gamble...Now right outside of Vegas you can actually have sex with women legally, so little fuck boy meet me in Vegas and I can get you some unprotected sex legally..because we all know how won't do anything illegal. Hell you might even tell on others who do.

I've heard that condoms are mandatory in those brothels.

Red1966 · Jul 21, 2014

londonfog said:
so when you meet men in Vegas they try to fuck you ??
When we meet up it's usually to see a fight or gamble...Now right outside of Vegas you can actually have sex with women legally, so little fuck boy meet me in Vegas and I can get you some unprotected sex legally..because we all know how won't do anything illegal. Hell you might even tell on others who do.

I've heard that condoms are mandatory in those brothels.

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