Ideally you'd want to defol right before flip - I missed this defol on my current grow and paid for it. You should be okay with defoling *lightly* right now. I'd take care of some of the bigger fan leaves now. I'm a fan of lolipopping them around day 21, removing the lower half of the plant essentially, clearing nodes that will be larf (energy suckers). There's quite a few schools of though on defoliation, it's about finding what you like and what works best for your grows.
This one should be a nice bushy monster though. May have to throw up another scrog to support the colas. Once you see 1 cola start leaning you need to do it that day or the next. I waited too long and walked into some horizontal colas yesterday lol.
Happy growing brother!