ganjames
Well-Known Member
[TABLE="class: wikitable"]
[TR]
[TH]
Name[/TH]
[TH]Structure[/TH]
[TH]Binding affinity for the CB[SUB]1[/SUB] receptor[/TH]
[TH]Binding affinity for the CB[SUB]2[/SUB] receptor[/TH]
[/TR]
[TR]
[TD]THC[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = 40.7±1.7 nm[SUP][26][/SUP][/TD]
[TD]K[SUB]i[/SUB] = 36.4±10 nm[SUP][26][/SUP][/TD]
[/TR]
[TR]
[TD]Cannabicyclohexanol[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = unknown. Reported to be 5 times more potent than THC, based on physiological responses in rats[SUP][27][/SUP][/TD]
[TD][/TD]
[/TR]
[TR]
[TD]HU-210[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = 234 pM (100–800 times more potent)[SUP][28][/SUP][/TD]
[TD][/TD]
[/TR]
[TR]
[TD]JWH-018[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = 9.00±5.00 nm[SUP][26][/SUP][/TD]
[TD]K[SUB]i[/SUB] = 2.94±2.65 nm[SUP][26][/SUP][/TD]
[/TR]
[TR]
[TD]JWH-073[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = 8.90±1.80 nm[SUP][26][/SUP][/TD]
[TD]K[SUB]i[/SUB] = 38.0±24.0 nm[SUP][26][/SUP][/TD]
[/TR]
[TR]
[TD]AM-2201[/TD]
[TD]
[/TD]
[TD]K[SUB]i[/SUB] = 1.0 nM[SUP][29][/SUP][/TD]
[TD]K[SUB]i[/SUB] = 2.6 nM[SUP][29][/SUP][/TD]
[/TR]
[/TABLE]
I found this chart on the 'Pedia. Synthetic cannabinoid-oids found in "spices" fall into two classes: the naphthoylindoles, which are dead easy to prep, and the tetrahydrobiphemyls, of which good ol' THC is the natural archetype. cn
there's a lot of these "AM" verities as well, and knowledge on some of these?
http://en.wikipedia.org/wiki/AM-2233