Everyone focuses on the source of materials, and that's groovy and all. I certainly fester over the local amendments I use.
Another equally huge issue is what happens when you introduce a bulk of nutrients. Nutrients somewhat locked up in fish meal, guano, etc often require microbes to release the ions, then store them and eventually release them back to the plant. The microbe / plant relationship is a fine dance. Doesn't happen when you bottle feed. You've significantly changed the soil dynamic, and the microbial profile changes. Microbes aren't storing / fetching Cations like they're supposed to. Plant cuts back on exudates, since the microbe symbiosis is gone. Microbes are out of a job.
People continuously and completely incorrectly assume that because they've inoculated their "soil" with microbes, that the microbes will flourish. People also assume if they inoculate with a microbial tea, that this might jump start that valuable plant / microbe relationship. It will not. If you bottle feed, you've changed the game.
That's perfectly fine. Folks grow stellar weed this way. Toke up brothers.
One big loss by firing all those microbes is a direct loss of some immune response. Same with animals and humans.