Pandemic 2020

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DIY-HP-LED

DIY-HP-LED

Well-Known Member
Budzbuddha said:
Trump “ presses “ FDA to use “ Plazma “ ( trump’s word ) to show a new therapeutic. Use of plasma antibodies from previous covid patients .


Hospitalized patients who received the plasma within three days of diagnosis, are under the age of 80 and not on mechanical ventilation, benefited the most, with a 35% improvement in survival 30 days after receiving the transfusion compared with patients who got plasma with low antibody levels, according to Dr. Marks.

“We’re confident that convalescent plasma is safe to use in this setting,” Dr. Marks added.

Convalescent plasma has been seen as a way to help people fight the disease and a bridge while other treatments are under development. The emergency-use authorization doesn’t alleviate the need for a vaccine or for therapies known as monoclonal antibodies that could stave off infection or at least reduce the seriousness of one.

Emergency-use authorization waives some regulatory requirements involved in using products during public health emergencies that aren’t yet FDA-approved..... Trump’s NOTHING NEWS to temper his polling free fall.
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A lot of lessons are being learned the hard way with covid, lessions in law, regulation and science too. The way gold standard double blind studies are done must be looked at, the methodology is correct, but the practical implementation is a serious problem with a fast moving target like covid. This problem has repeatedly surfaced with a number of treatments concerning covid, the lack of reliable data has lead to confusion and delays in understanding. I believe this will be studied and new methodologies and standards of temporary evidence will be implemented, some of this will require new regulations and laws.

I think an AI managed central database(s) of treatments, symptoms and outcomes might be helpful for future pandemics. Remove the biases as much as possible for treatments in real time as the data comes in and is machine processed, most biases could be isolated to the algorithm and dealt with there. Fast and reasonably accurate, usable results are the objective, automate and standardise the information processing system as much as you can to get them. Make every sick patient you can count towards the data set, it starts with a tests, a form and checklist. Give the right people the right information in the the proper format and the scientists, programmers and statisticians can find the accurate answers.
 
captainmorgan

captainmorgan

Well-Known Member
Budzbuddha said:
Trump “ presses “ FDA to use “ Plazma “ ( trump’s word ) to show a new therapeutic. Use of plasma antibodies from previous covid patients .


Hospitalized patients who received the plasma within three days of diagnosis, are under the age of 80 and not on mechanical ventilation, benefited the most, with a 35% improvement in survival 30 days after receiving the transfusion compared with patients who got plasma with low antibody levels, according to Dr. Marks.

“We’re confident that convalescent plasma is safe to use in this setting,” Dr. Marks added.

Convalescent plasma has been seen as a way to help people fight the disease and a bridge while other treatments are under development. The emergency-use authorization doesn’t alleviate the need for a vaccine or for therapies known as monoclonal antibodies that could stave off infection or at least reduce the seriousness of one.

Emergency-use authorization waives some regulatory requirements involved in using products during public health emergencies that aren’t yet FDA-approved..... Trump’s NOTHING NEWS to temper his polling free fall.
Click to expand...
Fucking lies, convalescent plasma has shown very little difference in studies so far. They have not done a blind study with placebos which would show one way or other if it is making any real difference, I posted about this months ago.
 
hanimmal

hanimmal

Well-Known Member
DIY-HP-LED said:
A lot of lessons are being learned the hard way with covid, lessions in law, regulation and science too. The way gold standard double blind studies are done must be looked at, the methodology is correct, but the practical implementation is a serious problem with a fast moving target like covid. This problem has repeatedly surfaced with a number of treatments concerning covid, the lack of reliable data has lead to confusion and delays in understanding. I believe this will be studied and new methodologies and standards of temporary evidence will be implemented, some of this will require new regulations and laws.

I think an AI managed central database(s) of treatments, symptoms and outcomes might be helpful for future pandemics. Remove the biases as much as possible for treatments in real time as the data comes in and is machine processed, most biases could be isolated to the algorithm and dealt with there. Fast and reasonably accurate, usable results are the objective, automate and standardise the information processing system as much as you can to get them. Make every sick patient you can count towards the data set, it starts with a tests, a form and checklist. Give the right people the right information in the the proper format and the scientists, programmers and statisticians can find the accurate answers.
Click to expand...


The Republicans after Obamacare passed and they used that to win the House to stop all bills to fix the dismantling they did in lawsuit spam. They stripped out all the innovations in the communications for our medical systems that Obama tried to get our nation.

https://www.vanityfair.com/news/politics/2013/09/republicans-know-obamacare-will-work
Screen Shot 2020-08-23 at 7.43.29 PM.pnghttps://www.vanityfair.com/news/politics/2013/09/republicans-know-obamacare-will-work
 
Fogdog

Fogdog

Well-Known Member
DIY-HP-LED said:
A lot of lessons are being learned the hard way with covid, lessions in law, regulation and science too. The way gold standard double blind studies are done must be looked at, the methodology is correct, but the practical implementation is a serious problem with a fast moving target like covid. This problem has repeatedly surfaced with a number of treatments concerning covid, the lack of reliable data has lead to confusion and delays in understanding. I believe this will be studied and new methodologies and standards of temporary evidence will be implemented, some of this will require new regulations and laws.

I think an AI managed central database(s) of treatments, symptoms and outcomes might be helpful for future pandemics. Remove the biases as much as possible for treatments in real time as the data comes in and is machine processed, most biases could be isolated to the algorithm and dealt with there. Fast and reasonably accurate, usable results are the objective, automate and standardise the information processing system as much as you can to get them. Make every sick patient you can count towards the data set, it starts with a tests, a form and checklist. Give the right people the right information in the the proper format and the scientists, programmers and statisticians can find the accurate answers.
Click to expand...
You are still hooked on the war analogy, where taking higher risks can be justified against the threat of losing the war. Loss in war means losing everything. So, yes, on the battlefield when one side is losing, that side is likely to accept horrendous losses to stave off defeat and the enemy doesn't know what the other side will do. Surprise in a war against a human opponent can help overcome an otherwise losing situation.

This is a medical emergency. The virus isn't "winning" and it can't be surprised or flanked or anything like that. The virus does what its RNA is designed to do. Humans respond to the virus, vaccines and treatments according to our own highly variable biology. We know a lot about this virus and the disease it causes in humans. There is much more that we don't know. As they say, you don't know what you don't know. If we move too fast, a promising new treatment can cause more problems than it solves due to what we don't know. We have plenty of experience to show us when corners are cut almost always we get surprised by the things we didn't know. To avoid doing harm new treatments are subjected to massive test programs. There is no good reason why we should stop following the tried and known effective test methods.

So, no. We should not change double blind test methodologies right now. That kind of change should be examined and tested every bit as rigorously as the vaccine. It must be rigorously tested according to standard practices before I'd consider taking it. Research into better methods is fine. Use this situation and fund research into better testing methodologies. But no, don't cut corners and shoot for the moon this time around. Rely on what we know works. Because a mistake will make everything worse and there is time for us to get it right.
 
captainmorgan

captainmorgan

Well-Known Member
tRUmp will do everything he can to get a vaccine released before the election by removing safety protocols, safe or not. If he can do this and it kills or injures a bunch of people the public trust in vaccines will be severely damaged.
 
Dr.Amber Trichome

Dr.Amber Trichome

Well-Known Member
captainmorgan said:
tRUmp will do everything he can to get a vaccine released before the election by removing safety protocols, safe or not. If he can do this and it kills or injures a bunch of people the public trust in vaccines will be severely damaged.
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Yeah I was thinking he would do that . He should have his family take the vaccine first just like his friend Vlad did with the first registered Covid 19 vaccine called the
Sputnik V. Out of Russia. Putin has his daughter injected as part of the trial.
haven’t heard much about the daughter for a while . They said she has a fever the first 3 days after getting the vaccine. I am currently reading a book about people getting vaccinated For a flu shot and then they get a high fever die and then turn into zombies.
 
Fogdog

Fogdog

Well-Known Member
Dr.Amber Trichome said:
Yeah I was thinking he would do that . He should have his family take the vaccine first just like his friend Vlad did with the first registered Covid 19 vaccine called the
Sputnik V. Out of Russia. Putin has his daughter injected as part of the trial.
haven’t heard much about the daughter for a while . They said she has a fever the first 3 days after getting the vaccine. I am currently reading a book about people getting vaccinated For a flu shot and then they get a high fever die and then turn into zombies.
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Yeah, I don't want to turn into a zombie. I'd be OK if it made me super smart or gave me a super power. But Zombies have bad breath. I want this vaccine tested right before its released.
 
Dr.Amber Trichome

Dr.Amber Trichome

Well-Known Member
Fogdog said:
Yeah, I don't want to turn into a zombie. I'd be OK if it made me super smart or gave me a super power. But Zombies have bad breath. I want this vaccine tested right before its released.
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Yes , I agree. Zombies smell very bad. If it isn’t the breath then it’s the dried blood and open wounds and just over all poor hygiene . That was So mean of Vlad to force his daughter to get injected. She was so pretty before the injection and now she looks A bit worn down.
CD733B60-837D-422F-BABD-BB20241C80D7.jpeg
 
topcat

topcat

Well-Known Member
captainmorgan said:
There's a reason why most vaccines take 10-15 years to develop and even that is no guarantee they can with this virus, Fauci has said recently that it looks promising but it's not a sure thing.
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The reason is: the stock market. Don't want to stifle Don Dolt's narrative. (Donald J Dolt has a good ring to it.) There will be no vaccine, or treatment before the election. Oh, Skyler, remember I said that.
 
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DIY-HP-LED

DIY-HP-LED

Well-Known Member
Fogdog said:
You are still hooked on the war analogy, where taking higher risks can be justified against the threat of losing the war. Loss in war means losing everything. So, yes, on the battlefield when one side is losing, that side is likely to accept horrendous losses to stave off defeat and the enemy doesn't know what the other side will do. Surprise in a war against a human opponent can help overcome an otherwise losing situation.

This is a medical emergency. The virus isn't "winning" and it can't be surprised or flanked or anything like that. The virus does what its RNA is designed to do. Humans respond to the virus, vaccines and treatments according to our own highly variable biology. We know a lot about this virus and the disease it causes in humans. There is much more that we don't know. As they say, you don't know what you don't know. If we move too fast, a promising new treatment can cause more problems than it solves due to what we don't know. We have plenty of experience to show us when corners are cut almost always we get surprised by the things we didn't know. To avoid doing harm new treatments are subjected to massive test programs. There is no good reason why we should stop following the tried and known effective test methods.

So, no. We should not change double blind test methodologies right now. That kind of change should be examined and tested every bit as rigorously as the vaccine. It must be rigorously tested according to standard practices before I'd consider taking it. Research into better methods is fine. Use this situation and fund research into better testing methodologies. But no, don't cut corners and shoot for the moon this time around. Rely on what we know works. Because a mistake will make everything worse and there is time for us to get it right.
Click to expand...
I did say there was nothing wrong with the double blind studies, in fact they provide the best evidence, the problems with covid studies are well documented and discussed by the scientific community. I'm speaking of things like permissions from hundreds of different hospitals across several justictions, the collection and processing of data, tools for a more effective approach. These are ways of getting proper studies underway quickly, facilitating them and efficiently collecting data. I'm merely speaking of better data collection, more speedy analysis, leveraging technology, the fundamentals of good science remain the same. I'm sure the scientific situation would be better with some leadership too, sadly that leadership was in place before Trump.

There are similarities to war in that there are lives on the line and to a degree, freedom to be gained, strategies and tactics informed by experience and logistical problems born of incompetence etc
 
DIY-HP-LED

DIY-HP-LED

Well-Known Member
captainmorgan said:
Fucking lies, convalescent plasma has shown very little difference in studies so far. They have not done a blind study with placebos which would show one way or other if it is making any real difference, I posted about this months ago.
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There are ethical as well as other issues at play here, doctors are very reluctant to include patients in placebo groups, among a host of other issues that plague the organisation of proper causation studies for a fast moving target like covid. Also leadership was lacking and convalescent plasma research and treatment was initiated ad hoc and later supported by the FDA.

Plasma therapy has a majority of expert opinion and some preliminary data going for it at this point, however there is a strong "signal" as they like to term it in the data. If things were organised properly we should have had definitive answers on convalescent plasma by now, yer dead or survive in a month with covid so answers should be forthcoming. I posted an article on the complexities of all this stuff a while back, the politics are another matter altogether.
 
DIY-HP-LED

DIY-HP-LED

Well-Known Member
Donald is touting plasma now, before his was hindering research into it, I posted news articles on it. Maybe he has some inside info on an about to be published study and wants to get ahead of the news? Another "miracle" cure?

How about a national lock down Donald? Treatments are nothing when compared to common fucking sense public health measures. Soon there might be 2000 dead a day in America, from a largely preventable disease. There are now even effective treatments that greatly improve the chances of survival, more so in the coming months, if the numbers to sick people were driven down to those of America's peer nations.
 
captainmorgan

captainmorgan

Well-Known Member
That's all fine and dandy but studies are coming out that say a large majority of covid patients are showing heart and vascular damage after their recovery, even the ones with mild cases. Bottom line is if you get it, you only have a small chance of coming out of it without long term damage. Without a safe and effective vaccine we are fucked, end of story.
 
topcat

topcat

Well-Known Member
captainmorgan said:
That's all fine and dandy but studies are coming out that say a large majority of covid patients are showing heart and vascular damage after their recovery, even the ones with mild cases. Bottom line is if you get it, you only have a small chance of coming out of it without long term damage. Without a safe and effective vaccine we are fucked, end of story.
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Too true. That's the way I see it. And...humanity needs a reset. Mother Nature is getting rid of it's vector, naturally, and that is us.
 
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