tell me why when i actually use my degrees and try to help.. no likes.
is it just too long to read? ive posted things that arent on the internet period. like my cdlsa, similar to acid. never studied or even theorized.
but i talk like an ignorant mafucker like i also am...lots of likes.
its frustrating
take a couple posts like this, or my posts on how curing actually works making
@SimonD disappear
ive done this many times
no likes
and lol at the fermentation theory someone spread
i mean this stuff is gold
cb1 receptors respond to the c-9 position of the cyclohexane ring, the phenolic hydroxyl and carbon/non polar side chains at c3...
check structure of win 55,not the dame class, not a terpenoid like thc. but look
napthalene ring - cyclohexane ring, carbonyl group -phenolic hydroxyl, and morpholinoethyl group..quite potent
thc binds through
2 oxygens a phenolic hydroxyl at position 1 and an oxygen pyran ring opposite,interacting through hydrogen bonding th cb leaving a lysine residue..the opening of the pyran ring not being significant...
as far as potency and activation..
acyclic ring was found to be better than a heterocyclic ring, with a cyclohexane ring being optimal. In addition, the size and the position of the substituent on the cyclic ring is important to maintenance of CB1 affinity...position of double bonds within the cyclohexane ring effect activity. For example, moving the double bond of 9-THC to position 8 (as in 8-THC) decreases CB1affinity. about 30%
methyl (less likely to hydrogen bond) ethyl etc generally kills short side chains kill activity, 4-6 is best, branched chain increases activity.. increasing ring size to say heptane increases activity of both, conversion to a pyran cuts cb2 .adding oxy, hydroxy ketones increase cb2 .a sulfur substitution anywhere ruins it.
oxy in the phenyl ring increases cb1 can't substitute the phenol or alter placement as I was mentioning about delta 8, serious alterations ruin it
, degree of saturation as well as the position of the double bond in the cyclohexane ring effects cb.
or how thc is produced...
so inside the trichomes
Geranyl pyrophosphate and a precursor to olivetolic acid react, a c12 (for pentyl) c10(for propyl)polyketide,then through cyclization yielding olivetolic acid..then catalyzed by an enzyme to produce cannabigerolic acid along with alkylation.. The production of Thc (and propyl)thcv cbd cbdv and cbc cbcv are controlled by 3 different enzymes Thca synthase being the enzyme converting cbga to thca through an oxidative cyclization of the geranyl group on cbga(of course this is all a bit, well really simplified for y'all) geranyl diphosphate + olivetolate =cannabigerolate + diphosphate.. cannabigerolate + O(2) = Delta(9)-tetrahydrocannabinolate + H(2)O(2)
and how you could help out these processes increasing production