If you research PureCrop1, it does everything but cure cancer and is pure as mothers milk...It's also very expensive. Nevertheless, I used it last year.
I grew two ILGM feminized GDP. They ended up 6' tall and produced 2.5lbs. I sprayed only neen oil every 10 days until the first pistols. After that I sprayed PureCrop1 at the recommended dose every Friday. I planned to use only PC1 until a week before harvest. Unfortunately, I started seeing catapillar eggs about 3 week in, and eventually pulled off a couple worms, so I had to add Bt. I couldn't risk it. A week before I planned to harvest, I found two buds with budrot. I ended up cutting them out and harvesting a week early.
In PC1's defense, coastal fog is common here and budrot and mold are real issues. Losing just two buds to rot is a GREAT year. I had no mites, no thrips, and only minor whiteflies. The plants did seem to like the PC1 foliar sprays, and were super healthy all the way to harvest.
In summary, it's not a cure all. It had no effect on budworms, and some impact on mold, but worked great on the little pests. This year I'm trying spinosad (bugs) and Monterey Complete Disease Control (bud rot).