Yeah, absolutely, thats how im using it. Theres still a learning curve for sure, ive found it a little harder to dial in than watering in nutrients, but it fits my grow style. I'm currently using ProMix HP+ with added perlite, Worm Castings and Gaia Green 4-4-4 then dressing with Gaia Green Flower nutes. Im honestly still getting the hang of it. Premixed super soil was the easiest to me but its just so expensive, at least where I'm at. Basically my advice is dont be afraid to expirement and dont buy anything in bulk until you know you like a method lol. I have an entire shelf of nutrients I didnt like at this point.
And dont get me wrong, EC meters can be very helpful, especially in straight hydro. Part of how I got away from using them was by selecting nutrients that were very simple and consistent like Veg+Bloom, Jack's or MegaCrop. V+B even self adjusts pH if you choose the right line for your water. There are definitely lines that will push yield further and maybe squeeze some extra trichs out, but I always get myself in trouble when I overcomplicate things in the pursuit of perfection.