Horticultural science has proven (not opinion, fact) that vegative propagation (aka cloning) produces a plant with an exact copy of the original DNA, and there is no degradation of any of its genetics, or traits. It is actually the same plant, not a "clone" like so many think from watching sci-fi movies.
So weather its keeping a mother plant for 30 years and taking cuttings, or taking a cutting, from a cutting, from cutting (once they stablize) the plant isn't going to change, and is the only possible way to preserve that plant, as seeds will have traits of the parents, but will have a new DNA and genetic makeup.
What does happen though, is people have different grow setups, lights, feeding, environmental factors, in which has a great deal of effect in how the plant grows and finishes, no matter how the mother was.