Synthetic nutrients contain chelated salt which is bad for fungi & bacteria. Any synthetic salts that you apply to your soil will kill most if not all of your microbeasties. Not saying your plant will die and wont still grow. Because it is "life", it will always have one main drive in its evolutionary cycle; survive. Just saying that it will really fuck your plant up and could shock the shit out of it. Those fungi & bacteria have created symbiotic relationships with your roots rhizosphere. The microbeasties NEED the plant to live. The plant NEEDS the microbeasties to live. The microbeasties are in a constant state of eat/shit/die/eat/shit/die which is how it feeds the plant. So when give your plants compost teas, don't think of it as "feeding the plant" because you really aren't. The plants roots will not and are not sorting and releasing the nutrients. The microbeasties are eating/shitting/dying, which in turn is feeding the plants. In exchange for nutrients the plant is giving the microbeasties carbs, in the form of glucose & sucrose, which is coming directly from photosynthesis.
Sooooooooooooo.... If you introduce highly toxic synthetic salts into this thriving micro colony which is "at one" (literally) with the cannabis plant, you will destroy this relationship and make it harder for your plant to uptake nutrients. Once you have applied the synthetic fertilizer it will take at least a month to get your soil back to what it used to be.