Does growing autos make sense...
No..
End of story
Does this post make sense? I was thinking describing win 55 killed it. I was just trying to show how its still a "cannabinoid"
As long as yiu dont try to play on words as cannabis is a "facultative photoperiodic" plant
With many equatorial sats autoflowering under certain conditions
Without going too much into the pharmacological aspects. Thca will cross the blood brain barrier in high doses. Our pets having a much greater reaction. Binding affinities many times stronger will still feel effects unlike humans.
Cbd acts on some 11 pathways not counting those indirect. This occurs in the brain. There are cb2 receptors outside the brain that can be hit to reduce inflammation. But opiate receptors wont be hit for example among many others. Whats commonly misunderstood is thc has relatively similar binding affinities for both cb1 and cb2.
Thc binds..well specifically
cb1 receptors respond to the c-9 position of the cyclohexane ring, the phenolic hydroxyl and carbon/non polar side chains at c3...
check structure of win 55,napthalene ring and cyclohexane ring, carbonyl group and phenolic hydroxyl, and morpholinoethyl group
2 oxygens a phenolic hydroxyl at position 1 and an oxygen pyran ring opposite,interacting through hydrogen bonding with a lysine residue,the opening of the pyran ring not being significant...
Now not only does this carboxyl group -cooh ..nitice the oxygens and hydrogen..alter this hydrogen bonding
When we look at synthetic cannabinoids in drug design..
acyclic ring was found to be better than a heterocyclic ring, with a cyclohexane ring being optimal. In addition, the size and the position of the substituent on the cyclic ring is important to maintenance of CB1 affinity...position of double bonds within the cyclohexane ring effect activity. For example, moving the double bond of 9-THC to position 8 (as in delta8-THC) decreases CB1affinity. Bu about 30%
methyl (less likely to hydrogen bond) ethyl etc generally kills short side chains kill activity, 4-6 is best, branched chain increases activity.. increasing ring size to say heptane increases activity of both, conversion to a pyran cuts cb2 .adding oxy, hydroxy ketones increase cb2 .a sulfur substitution anywhere ruins it.
oxy in the phenyl ring increases cb1 can't substitute the phenol or alter placement as I was mentioning about delta 8, serious alterations ruin it
, degree of saturation as well as the position of the double bond in the cyclohexane ring effects cb1
I could literally carry on for a whole page.. receptor binding.. relies on the 3 things mentioned in my post above with slight variations drastically altering binding affinity and huge changes kill it. As decribed
So again the addition of the polar -cooh decreases activity butvit also effects the logp of the compound
Cbd logp in the high 6's thc Bout 7
In practice optimum colonic absorption is 1.32, intestinal is 1.35, oral 1.8, Cns 2, percutaneous at 2.6 and sublingual 5.5.
So this effects how we make the base to get the polar cbda into the skin
I rampbled like fuck and prolly made nosense...im not a vet and not completely sure on any pharmacological differences among humans and yur pets. But between 20 and 30 fold increase in potency is known